Pentasa Suppositories

Pentasa suppositories treat ulcerative colitis in the rectum.

Pentasa suppositories are a prescription medicine that treats ulcerative colitis in the rectum, called ulcerative proctitis (or just proctitis).

Pentasa suppositories contain mesalazine (also known as 5-aminosalicylic acid or 5-ASA), in a sustained release base10, and work by coming into direct contact with inflamed tissue in the rectum and calming down the inflammation.

To come in direct contact with inflamed tissue in the rectum Pentasa suppositories are administered into the rectum, usually at bedtime. 


Pentasa suppositories deliver mesalazine directly to the inflamed tissue of the rectum, right where it is needed to calm down inflammation.

How to use Pentasa suppositories

How to use suppositoriesPentasa suppositories are normally used at bedtime. Prior to administering the suppository visit the toilet to empty the bowels. The suppository will work better if the bowel is emptied. Administer the suppository as follows: 

  1. Open the foil pack.
  2. Put one of the finger protectors provided on the finger with which you will insert the suppository.
  3. To aid insertion the suppository can be moistened with water prior to use. The suppository must not be lubricated with petroleum jelly, glycerol or oil based lubricants such as baby oil, creams and liquid paraffin.
  4. Insert the suppository gently and fully into the rectum. It may help to do this by lying down on one side and raising the other knee as shown in the diagram
  5. Remain still for a few minutes after insertion to help retain the suppository. If the suppository comes out within 10 minutes, a new one should be inserted.
  6. Dispose of the used finger protector safely and wash your hands.

Always use your medicines as prescribed and seek advice from your doctor, IBD nurse or pharmacist if you need it so you can feel comfortable and confident using Pentasa suppositories. 

FAQ About Pentasa Suppositories

I have not heard of administering medicine rectally before. Is this common?

Administering medicine into the rectum is common. Examples of other medicines that can be adminsitered as suppositories and/or enemas into the rectum are pain relief, other anti-inflammatory (steroid), and antibiotic medicines.

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Pentasa Tablets 500mg, Pentasa Enema 1g/100 ml, Pentasa Suppository 1g, Pentasa Granules (Sachets) 1g.

The information provided in this website is not intended to replace advice given by your doctor, pharmacist or other healthcare professional. If you have any concerns about your health and or treatments please consult a doctor, pharmacist or other healthcare professional. Consult your doctor to see if this medicine is right for you.

Important Consumer Information

Do not use Pentasa if you have an allergy to any medicine containing mesalazine or aspirin-like medicines, or to any of Pentasa's ingredients. Do not use Pentasa if you have a severe kidney or liver problem. Pentasa should be used with caution during pregnancy and lactation.Side effects:All medicines can have side effects. Sometimes they are serious but most of the time they are not. Do not be alarmed by the following lists of side effects. You may not experience any of them.Common side effects include: headache, diarrhoea, abdominal pain, nausea and vomiting, rash. For enemas and suppositories also any pain or itching of the anus or rectum, rectal discomfort and urge to have a bowel movement.Tell your doctor or pharmacist if you notice any of these side effects and they worry you. The following list includes serious side effects which may need medical attention. Serious side effects are rare.Tell your doctor as soon as possible if you notice any of the following: bruising easily, unusual bleeding (e.g. nosebleeds), or frequent signs of infection such as fever, chills, sore throat and mouth ulcers; muscle aches and pains; painful joints; severe upper stomach pain; chest pain, sometimes spreading to the neck and shoulders, or with fever; yellowing of the skin/eyes, increased sensitivity of your skin to sun and ultraviolet light; worsening of your condition. The following list includes very serious side effects that may need urgent medical attention. These side effects are very rare. If you notice any of the following, tell your doctor immediately or go to Accident and Emergency at your nearest hospital: Sudden signs of allergic reactions such as rash, shortness of breath, swelling of limbs, face, lips, mouth, tongue or throat which may cause difficulty swallowing or breathing. Severe stomach cramps and/or pain, bloody diarrhoea, fever and severe headache. Rash with severe blisters and bleeding of the eyes, mouth, lips, nose and genitals. This website does not contain all the consumer medicines information. For full consumer medicines information, please refer to or your pharmacist. Always read the label. Use strictly as directed. If symptoms continue or you have side effects, see your doctor, pharmacist or health professional.

Pentasa Tablets 500mg, Suppositories 1g, Enemas 1g/100 ml,and Granules (Sachets) 1g are funded prescription medicines. Doctor's charges will apply.